Module 4. Effects of altered volume of distribution on plasma concentrations.

Objectives

Having completed this exercise and based on pharmacokinetic constants and data, students should be able to:

Significance

Exercise

Download vz.xlsx, the worksheet for this module. Depending on your settings, you may have to "enable editing" in order to make the changes suggested by the exercise.

Pharmacokinetic variables on the spreadsheet are preset for a typical adult horse (#1) and "typical" neonate (#2) given gentamicin.

Target Concentrations

Manipulate Dosage

Inspect

Caculated values

Steady-State Concentrations (for repeated doses during therapy).

Graphs

Assess