Concepts

Reference
Frazier DL; Aucoin DP; Riviere JE: Gentamicin pharmacokinetics and nephrotoxicity in naturally acquired and experimentally induced disease in dogs. J Am Vet Med Assoc (HAV), 1988 Jan 1; 192 (1): 57-63.

Significance
Occasionally (geriatric animal that acquires an infection while on adequate doses of enrofloxacin) it is necessary to use aminoglycoside antibiotics in the presence of renal dysfunction. It is important that appropriate doses and intervals are used in order to produce safe and effective therapy.