Theophylline

Why?

Low therapeutic index

When?

How?

Determine concentration at steady state

Alter Dosage using techniques described for digoxin or use table:

Concentration Result (mg/ml)	Modification
< 9.9	25% increase in dose rate
10 - 14.9	No Change
15 - 19.9	Decrease dose rate by 10%
20 - 24.9	Decrease dose rate by 25%
25 - 30	Skip dose, decrease dose rate by 25%
> 30	Skip dose, decrease dose rate by 50%