Module 2 questions - Dose rate and dose interval (General principles)
  1. Which is true?
    1. Cave for 5 mg/kg q12H is less than Cave for 5 mg/kg q8H
    2. Cave for 5 mg/kg q12H is greater than Cave for 5 mg/kg q8H
    3. Cave for 5 mg/kg q12H equal to Cave for 5 mg/kg q8H
  2. Which dosage would double Cave of a 2 mg/kg q12H dosage regimen?
    1. 2 mg/kg q6H
    2. 4 mg/kg q24H
  3. These dosages would produce the same Cave. Which dosage would have a higher Cmax?
    1. 2 mg/kg q12H
    2. 4 mg/kg q24H
  4. Based on the worksheet values for this module, show calculations for an intravenous dose (continue the 12 hour interval) to produce the same Cave (Calculated Value) as for simulation #2 at the end of the exercise.
    1. Cave is 53.333 mg/l (μg/ml) and Clt is 0.0045 l/hr/kg
    2. The equation that determines Cave for intravenous administration is
      • Cave = DoseRate / Clt (Note that F is included if the route is not IV)
      • re-arrange the equation to solve for DoseRate
      • Cave x Clt = DoseRate
    3. 53.333 μg/ml (mg/l) x 0.0045 l/hr/kg = 0.24 mg/kg/hr and,
      • DoseRate x Interval = Dose
    4. 0.24 mg/kg/hr x 12 hr = 2.88 mg/kg