- Which is true?
**C**_{ave} for 5 mg/kg q12H is less than C_{ave} for 5 mg/kg q8H
- C
_{ave} for 5 mg/kg q12H is greater than C_{ave} for 5 mg/kg q8H
- C
_{ave} for 5 mg/kg q12H equal to C_{ave} for 5 mg/kg q8H
- Which dosage would double C
_{ave} of a 2 mg/kg q12H dosage regimen?
**2 mg/kg q6H**
- 4 mg/kg q24H
- These dosages would produce the same C
_{ave}. Which dosage would have a higher C_{max}?
- 2 mg/kg q12H
**4 mg/kg q24H**
- Based on the worksheet values for this module, show calculations for an intravenous dose (
__continue the 12 hour interval__) to produce the same C_{ave} (Calculated Value) as for simulation #2 at the end of the exercise.
- C
_{ave} is 53.333 mg/l (μg/ml) and C_{lt} is 0.0045 l/hr/kg
- The equation that determines C
_{ave} for intravenous administration is
- C
_{ave} = DoseRate / C_{lt} (*Note that F is included if the route is not IV*)
- re-arrange the equation to solve for DoseRate
- C
_{ave} x C_{lt} = DoseRate
- 53.333 μg/ml (mg/l) x 0.0045 l/hr/kg = 0.24 mg/kg/hr and,
- DoseRate x Interval = Dose
- 0.24 mg/kg/hr x 12 hr =
**2.88 mg/kg** **
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