Module 3 questions - Altered clearance (General prinicples)

  1. Describe the effect that renal dysfunction might have on antibacterial activity (assume the infection is in the lungs).

    Renal dysfunction increases plasma concentrations associated with doses of aminoglycosides (and other drugs of course). Increasing the plasma concentrations of an antibiotic in a patient with an infection SHOULD improve the odds that therapy will kill bacteria.

  2. Is gentamicin given according to pulse dosing principles (3x dose, 24 hour interval) safe for patients with clinically normal renal function (based on routine evaluation)?

    It appears that a safe Cmin (below 1.0) is reached for patients with (at least) 50% loss of renal function.

  3. Is gentamicin given according to pulse dosing principles (3x dose, 24 hour interval) safe for patients with any level of renal function (including overt renal failure)?

    At 75% loss of renal function, Cmin concentrations are unsafe (above 1.0) even when using the pulse-dose regimen.

  4. Which of the following statements are true?
    1. Incorrect dosing of aminoglycosides can be effective against the bacteria and toxic to the patient.
    2. Incorrect dosing of aminoglycosides can be ineffective against the bacteria and not toxic to the patient.
    3. Correct dosing of aminoglycosides can be effective against the bacteria and not toxic to the patient.
    4. All three statements are true.