- The model described in this exercise is dose independent. When dosage is changed in such a model, which of these does not change (list all that apply)? Cmax, Cave, Cmin, Clt, Vz, T1/2
- Assume that moderate analgesia requires a plasma concentration of 30 μg/ml. Based on the information in this module and for a dog, can an oral dose regimen for aspirin be designed to produce moderate analgesia without toxicity for an entire 12 hour dose interval?
- According to the plasma concentrations, how long was mild analgesia maintained after a 10 mg/kg oral dose? after a 20 mg/kg oral dose?
- Which calculated value conveniently approximates the increase in the length of time achieved (duration of a particular effect) when increasing the dose from 10 to 20 mg/kg?