Module 1 questions - Dose Manipulation (General principles)
  1. The model described in this exercise is dose independent. When dosage is changed in such a model, which of these does not change (list all that apply)? Cmax, Cave, Cmin, Clt, Vz, T1/2
  2. Assume that moderate analgesia requires a plasma concentration of 30 μg/ml. Based on the information in this module and for a dog, can an oral dose regimen for aspirin be designed to produce moderate analgesia without toxicity for an entire 12 hour dose interval?
  3. According to the plasma concentrations, how long was mild analgesia maintained after a 10 mg/kg oral dose? after a 20 mg/kg oral dose?
  4. Which calculated value conveniently approximates the increase in the length of time achieved (duration of a particular effect) when increasing the dose from 10 to 20 mg/kg?