Module 4 questions - Altered volume of distribution (General principles)

  1. Estimate a dose of gentamicin would produce a Cmax in foals similar to that of adults dosed at 9.0 mg/kg q24H? (The number need not be exact. However, you may use the Excel worksheet for this purpose if you wish)
  2. Any potential for drug accumulation with repeated doses is reduced directly by:
    • Decreasing the dose
    • Increasing the dose interval
  3. Defend this statement: "Dosing a foal as if it were an adult creates the risk of producing gentamicin toxicity without efficacy."