- What two pharmacokinetic constants account for the differences between Na ampicillin and ampicillin trihydrate given intramuscularly?>
- If the pharmacokinetic model is dose independent (as implied in this module and the associated worksheet), doubling the dose (same interval) should double the steady state concentrations. It is actually quite likely that the absorption kinetics of ampicillin trihydrate are dose dependent. If this is so, doubling the dose should produce
- more than a doubling of the steady state concentrations.
- less than a doubling of steady state concentrations.
- A clinical patient of yours has received several doses of IV Ampicillin sodium (for a suspected gram negative infection) and appears to be responding. Your technician informs you that "no more veins are available". Do you choose IM Ampicillin sodium (#2) or IM Ampicillin trihydrate (#3) to acheive the SAME clinical effect?
- Based on your answer for question 3, do you need to give a larger total dose or can it remain approximately the same?