Module 8 questions - Extreme volumes (Clinical challenge)
  1. What physiologic and biochemical change or changes result in increased hepatic clearance associated with enzyme induction?
  2. What physiologic and biochemical change or changes result in decreased hepatic clearance associated with hepatic failure?
  3. Does the change in the fraction of an oral dose absorbed add to the effect of altered clearance or does it counter the effect?
  4. For which of the following dogs should the dosage of phenobarbital be adjusted (immediately)?
    1. A dog whose seizures are well controlled at 120 days but with a phenobarbital Cave lower than during the second week.
    2. A dog whose seizures are not well controlled during the second week and whose phenobarbital Cave is 30 μg/ml.