Module 9 questions - Extreme volumes (Clinical challenge)
  1. List the most (clinically) important differences in calculated values between adults and foals.
  2. What general recommendations can be made for the proper dose and interval of aminoglycosides given to neonatal foals?
  3. Examine the plot of the plasma concentration profile for the foal after you make your final dose adjustment. The plasma concentrations are below MIC for typical sensitive organisms (2.0 - 3.0 μg/ml) for about 6 hours out of each dose interval. What could you do for this patient to provide continuous antimicrobial therapy without risking gentamicin intoxication? (It should be clear that changing doses and intervals of gentamicin will not work. You need to think outside the pharmacokinetic box.)