Virginia-Maryland Regional College of Veterinary Medicine

 

KinetiClass is an interactive pharmacokinetics teaching tool. Microsoft Excel® spreadheets are provided to demonstrate a variety of concepts that apply to clinical veterinary patients. Calculations are believed to be accurate but the authors make no warranty concerning their use in actual patients.

KinetiClass
Laboratory Exercises
Basic Principles (Part I)
Exercise Subject
Dose (Ia) Effects of dose manipulation on the plasma concentration.
Dose Rate (Ib) Effects of dose rate and dose interval (repeated administration) on plasma concentration.
Elimination (Ic) Effects of changes of clearance on plasma concentration.
Distribution (Id) Effects of changes in volume of distribution on plasma concentration.
Clinical Scenarios (Part II)
Exercise Subject
Chloramphenicol (IIa) Species differences in pharmacokinetics (Cats are not small dogs).
Varying Dose and Interval
(IIb)
Clinical implications of different dosing protocols on antibiotic safety and efficacy.
Route of Administration
   and Dose Form (IIc)
Effect of route of administration and dose form on the performance (clinical effect) of drug products.
Clearance (IId) Effect of chronic drug administration on concentration due to induction of hepatic enzymes.
Volume of Distribution (IIe) Relationship between volume of distribution and clearance. Effect of volume of distribution (only) changes.
Elimination Rate Constant /
Half-life (IIf)
Relationship between volume of distribution and clearance. Effect of clearance (only) changes.

The exercises labeled Basic Principles (Part I) are meant to familiarize you with a few fundamental pharmacokinetic concepts. It is also intended to introduce you to the KinetiClass lab spreadsheets and how to use them. Finally, it provides you with an opportunity to examine both linear and semi-logarithmic plots of plasma concentration data and (hopefully) to understand strengths and weaknesses of each view.

The exercises labeled Clinical Scenarios (Part II) expand on the basic pharmacokinetic concepts outlined under "Basic Principles". These exercises emphasize multiple doses in order to introduce concepts such as "steady-state" drug accumulation. All of the exercises are based on clinical problems that have a pharmacokinetic basis and all are supported by pharmacokinetic literature citations.

Click on the name of an exercise to go there.


Dr. Jeff R. Wilcke, DVM, MS, DACVCP - Author
Dr. Dennis J. Blodgett, DVM, PhD, DABVT - Consultant
Dr. Virginia R. Fajt, DVM, PhD, DACVCP

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PLEASE NOTE:
  1. Different web browsers display web pages differently. This site has been extensively tested using Internet Explorer® and Firefox® on Windows 7® based machines and using Firefox® on MacIntosh® OS 10.x machines. No warranty has been made for functionality of Safari®, Google Chrome® or other browsers. There is no specific reason to think these will NOT work, but styles of buttons, windows and fonts may be different from those displayed by other browsers.
  2. This laboratory uses Microsoft Excel® In order to use the interactive features of the spreadsheets you must have Microsoft Excel® (Office 98 - Macintosh or Office 97 -Windows or newer) installed on your computer. The author has tested the spreadsheets using Open Office® and found that calculations are performed correctly but Open Office line graphs will only display two sets of data on the same graph. Some of these exercises display as many as 4 sets of data on each graph.
  3. When you choose to view a spreadsheet, the "download" behavior will depend on the operating system you use and the browser plug-ins you have installed. Newer versions of Internet Explorer® will display the spreadsheets in the browser window. Firefox will initiate a download of the spreadsheet. In the later case, the spreadsheet will need to be opened by your spreadsheet software.